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A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity.

机译：具有双重DNA结合和组蛋白脱乙酰基酶抑制活性的新型抗癌双功能铂药物候选物。

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摘要

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.

机译：描述了具有DNA结合，组蛋白脱乙酰基酶抑制活性和对癌细胞增强的选择性的新型多功能铂药物候选物的成功设计和合成。

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Griffith Darren; Morgan Maria P; Marmion Celine J;
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年度 2009
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1. A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity [J] . Darren Griffith, Maria P. Morgan, Celine J. Marmion Chemical Communications . 2009,第44期

机译：具有双重DNA结合和组蛋白脱乙酰基酶抑制活性的新型抗癌双功能铂药物候选物
2. The histone deacetylase inhibitor MGCD0103 has both deacetylase and microtubule inhibitory activity. [J] . Chia K, Beamish H, Jafferi K, Molecular pharmacology. . 2010,第3期

机译：组蛋白脱乙酰基酶抑制剂MGCD0103同时具有脱乙酰基酶和微管抑制活性。
3. Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase [J] . Raji Idris, Yadudu Fatima, Janeira Emily, Bioorganic and medicinal chemistry . 2017,第3期

机译：具有强效抑制活性的双官能缀合物，朝环氧氢酶和组蛋白脱乙酰酶
4. Theoretical Studies on the Inhibitory Activity of Levofloxacin-thiadiazole HDACi Conjugates to Histone Deacetylases [C] . Zi-qiang TANG, Chang-ning LIU, Yu-sheng LIU, International Conference on Biological Sciences and Technology . 2018

机译：Levofloxacin-Thiadozole HDACI缀合物与组蛋白脱乙酰酶抑制活性的理论研究
5. 1alpha,25-dihydroxyvitamin D3 Agonist and Histone Deacetylase Inhibitor Bifunctional Ligand Discovery Virtual Docking, Synthesis, Fluorescence Polarization-Based Screening, and Molecular Dynamics Simulations . [D] . Burger, Melanie C. 2011

机译：1alpha，25-dihydroxyvitamin D3激动剂和组蛋白脱乙酰基酶抑制剂双功能配体的发现虚拟对接，合成，基于荧光偏振的筛选和分子动力学模拟。
6. Bifunctional Conjugates with Potent Inhibitory Activity Towards Cyclooxygenase and Histone Deacetylase [O] . Idris Raji, Fatima Yadudu, Emily Janeira, -1

机译：具有对环加氧酶和组蛋白脱乙酰基酶具有抑制作用的双功能共轭物。
7. Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug [O] . Li Meiyi S.M. Massachusetts Institute of Technology 2012

机译：phenanthriplatin（一种新型单功能铂类抗癌药物候选药物）与顺铂（一种典型的双功能抗癌药物）的比较

A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity.

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