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Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.

机译:在炎症性肠病中用于结肠靶向药物递送的口服纳米递送系统的进展:选择性靶向患病与健康组织。

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摘要

Colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and enables localized treatment, which reduces systemic toxicity. Targeted delivery of therapeutics to the colon is particularly advantageous for the treatment of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. Advances in oral drug delivery design have significantly improved the bioavailability of drugs to the colon; however in order for a drug to have therapeutic efficacy during disease, considerations must be made for the altered physiology of the gastrointestinal (GI) tract that is associated with GI inflammation. Nanotechnology has been used in oral dosage formulation design as strategies to further enhance uptake into diseased tissue within the colon. This review will describe some of the physiological challenges faced by orally administered delivery systems in IBD, the important developments in orally administered nano-delivery systems for colon targeting, and the future advances of this research.
机译:结肠靶向药物递送是影响结肠的局部疾病的活跃研究领域,因为它提高了治疗剂的功效并实现了局部治疗,从而降低了全身毒性。将治疗剂靶向递送至结肠对于治疗炎性肠病(IBD)特别有利,所述炎性肠病包括溃疡性结肠炎和克罗恩氏病。口服药物递送设计的进步显着提高了药物对结肠的生物利用度。然而,为了使药物在疾病期间具有治疗功效,必须考虑与胃肠道炎症相关的胃肠道(GI)生理变化。纳米技术已被用于口服剂量制剂设计中,作为进一步增强对结肠内病变组织的摄取的策略。这篇综述将描述IBD口服给药系统所面临的一些生理挑战,结肠靶向纳米给药系统的重要进展以及这项研究的未来进展。

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