Inter-regional connectivity within the win/loss anticipation network in depressed individuals with bipolar disorder, in depressed individuals with major depressive disorder and healthy controls

摘要

Identifying biomarkers distinguishing depressed individuals with bipolar disorder (BDD) from those with major depressive disorder (MDD) would help to develop better therapeutic strategies and improve treatment outcomes. Depressed individuals are often biased (i.e., pessimistic bias) in their anticipation of future negative outcomes. Goal: to determine the differences in connectivity within the reward anticipation network between BDD, MDD and HC (healthy controls) using a graph modelling method. BDD had denser connectivity among fronto-striatal regions, while MDD had denser connectivity among occipital regions. BDD and MDD had similar fronto-striatal connectivity that was less dense compared to HC. Altered fronto-striatal and occipital connectivity patterns during win anticipation distinguished BDD from MDD and HC and might reflect a neurobiological mechanism for impaired processing of positive stimuli in BDD.