首页> 外文OA文献 >Plla/triethyl Citrate Membrane As An Alternative For The Treatment Of Skin Wounds [implante De Membranas De Plla/trietil-citrato Como Alternativa No Tratamento De Feridas Cutâneas]
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Plla/triethyl Citrate Membrane As An Alternative For The Treatment Of Skin Wounds [implante De Membranas De Plla/trietil-citrato Como Alternativa No Tratamento De Feridas Cutâneas]

机译:Plla /柠檬酸三乙酯膜替代治疗皮肤伤口[Plla /柠檬酸三乙酯膜植入替代治疗皮肤伤口]

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摘要

Bioresorbable polymers can be applied as membranes to sustain and guide cell growth through the regeneration process. This study evaluated poly(acid lactide), PLLA, membranes with addition of 10% triethyl citrate as skin wound healing in Wistar rats. Initially a 2cm2 skin wound was exercised of the back of 24 animals. The animals were divided into two groups: treated, whose the polymer membrane was implanted, and control, in which the wound was kept exposed. The results obtained after 1, 3, 7 and 15 days showed an inflammatory response more satisfactory in the implanted wounds, with early repair and collagen more organized when compared to exposed wounds. In addition to, the protected areas showed no irritant inflammatory response which could be attributed to the membrane. Thus, we conclude that the PLLA/Triethyl citrate membrane has effectively protected the wounds, allowing the repair and presenting itself as a promising skin dressing.
机译:可生物吸收的聚合物可用作膜,以通过再生过程维持和引导细胞生长。这项研究评估了添加10%柠檬酸三乙酯的聚乳酸丙交酯,PLLA膜作为Wistar大鼠皮肤伤口的愈合情况。最初,对24只动物的背部进行2cm2的皮肤伤口锻炼。将动物分为两组:被治疗的动物,其植入了聚合物膜;和对照组,其伤口保持暴露。在1、3、7和15天后获得的结果表明,与暴露的伤口相比,在植入的伤口中炎症反应更令人满意,并且早期修复和胶原组织性更高。另外,保护区没有显示出可归因于膜的刺激性炎症反应。因此,我们得出结论,PLLA /柠檬酸三乙酯膜已有效地保护了伤口,使其得以修复,并呈现出有希望的皮肤敷料。

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