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Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

机译:地衣中酚类化合物对一氧化氮和过氧化氢产生的免疫刺激作用

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摘要

The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
机译:为了了解它们可能的免疫调节特性,使用鼠类巨噬细胞研究了从巴西地衣中分离的化合物及其衍生物对H 2O 2和NO产生的影响。使用MTT测定法研究化合物的细胞毒性。通过确定瑞士小鼠腹膜巨噬细胞培养物上清液中的NO(格里斯测定)和H 2O 2(辣根过氧化物酶/酚红)来评估巨噬细胞刺激。这项研究证明了从地衣中分离出的一些酚类化合物及其衍生物对H 2O 2和NO的刺激活性。构效关系建议了进一步提高免疫活性的几种合成方向。

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