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A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

机译：雷帕霉素复合物1/2（mTORC1）/ V-Akt鼠胸腺瘤病毒致癌基因同源物1（AKT1）/组织蛋白酶H轴的机械靶标控制皮肤中丝聚蛋白的表达和加工，这是特应性皮炎患者皮肤屏障破坏的新机制

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Naeem Aishath S.; Tommasi Cristina; Cole Christian; Brown Stuart J.; Zhu Yanan; Way Benjamin; Willis Owen Saffron A. G.; Moffatt Miriam; Cookson William O.; Harper John I.; Di W. L.; Brown Sara J.; Reinheckel Thomas; OShaughnessy Ryan F. L.;
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1. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [J] . Naeem Aishath S., Tommasi Cristina, Cole Christian, The Journal of Allergy and Clinical Immunology . 2017,第4期

机译：雷帕霉素复合物的机械靶标1/2（mTorc1）/ V-akt鼠胸腺瘤病毒癌基因同源物1（akt1）/组织蛋白酶H轴控制皮肤中的叶片表达和加工，一种新的皮肤屏障患者皮肤屏障中断的特应性皮炎患者
2. AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways [J] . HoC., WangC., MattuS., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2012,第3期

机译：小鼠肝脏中的AKT（v-akt鼠胸腺瘤病毒癌基因同源物1）和N-Ras（神经母细胞瘤ras病毒癌基因同源物）共激活通过mTOR（雷帕霉素复合物1的哺乳动物靶标），FOXM1（前叉框M1）促进快速致癌作用。 / SKP2和c-Myc途径
3. V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis [J] . EvertM., CalvisiD.F., EvertK., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2012,第5期

机译：V-AKT鼠胸腺瘤病毒致癌基因同系物/哺乳动物雷帕霉素激活靶标诱导了一系列代谢变化，从而促进了胰岛素诱导的肝癌发生
4. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin a novel mechanism for skin barrier disruption in patients with atopic dermatitis [O] . Aishath S. Naeem, Cristina Tommasi, Christian Cole, -1

机译：雷帕霉素复合物1/2（mTORC1）/ V-Akt鼠胸腺瘤病毒致癌基因同源物1（AKT1）/组织蛋白酶H轴的机械靶标控制皮肤中丝聚蛋白的表达和加工这是特应性皮炎患者皮肤屏障破坏的新机制
5. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [O] . Naeem, AS, Tommasi, C, Cole, C, 2016

机译：雷帕霉素复合物1/2（mTORC1）/ V-akt鼠胸腺瘤病毒癌基因同源物1（aKT1）/组织蛋白酶H轴的机制靶点控制皮肤中丝聚蛋白的表达和加工，这是特应性皮炎患者皮肤屏障破坏的新机制。

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

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