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Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

机译：针对具有体外纳摩尔亲和力的冯·希尔佩尔-林道（VHL）E3泛素连接酶和缺氧诱导因子（HIF）α亚基之间的蛋白质-蛋白质相互作用的小分子的结构指导设计和优化

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Galdeano Carles; Gadd Morgan S.; Soares Pedro; Scaffidi Salvatore; Van Molle Inge; Birced Ipek; Hewitt Sarah; Dias David M.; Ciulli Alessio;
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年度 2014
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1. Structure-Guided Design and Optimization of Small Molecules Targeting the Protein?Protein Interaction between the von Hippel? Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities [J] . Carles Galdeano, Morgan S. Gadd, Pedro Soares, Journal of Medicinal Chemistry . 2014,第20期

机译：针对小分子的蛋白质-蛋白质相互作用的小分子结构指导设计与优化Lindau（VHL）E3泛素连接酶和缺氧诱导因子（HIF）α亚基的体外纳摩尔亲和力。
2. Targeting the von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1a Interaction [J] . Dennis L. Buckley, Inge Van Molle, Peter C. Gareiss, Journal of the American Chemical Society . 2012,第10期

机译：使用小分子靶向von Hippel-Lindau E3泛素连接酶来破坏VHL / HIF-1a相互作用
3. QSAR modeling and in silico design of small-molecule inhibitors targeting the interaction between E3 ligase VHL and HIF-1 alpha [J] . Pan Jing, Zhang Yanmin, Ran Ting, Molecular diversity . 2017,第3期

机译：QSAR建模和靶向E3连接酶VHL和HIF-1α之间相互作用的小分子抑制剂的硅设计
4. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue inhypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex [C] . David R. Mole, Christopher W. Pugh, Peter J. Ratcliffe, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：HIF途径的调节：保守脯氨酰残基的酶促羟基化inhypymoxia-Invucient因子α亚基治理PVHL E3泛素连接酶复合物捕获
5. Development of Ligands for the von Hippel-Lindau E3 Ligase and Their Use in PROTACs, Small Molecule Inducers of Protein Degradation. [D] . Buckley, Dennis. 2013

机译：von Hippel-Lindau E3连接酶配体的开发及其在PROTAC（蛋白质降解的小分子诱导剂）中的应用。
6. Structure-Guided Design andOptimization of SmallMolecules Targeting the Protein–Protein Interaction betweenthe von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the HypoxiaInducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities [O] . Carles Galdeano, Morgan S. Gadd, Pedro Soares, -1

机译：结构导向的设计和优化小靶向蛋白质与蛋白质之间相互作用的分子von Hippel–Lindau（VHL）E3泛素连接酶和缺氧具有体外纳摩尔亲和力的诱导因子（HIF）α亚基
7. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. [O] . Galdeano, Carles, Gadd, Morgan Stuart, Soares, Pedro, 2014

机译：针对小分子的结构指导设计和优化，这些小分子针对具有体外纳摩尔亲和力的von Hippel-Lindau（VHL）E3泛素连接酶和缺氧诱导因子（HIF）α亚基之间的蛋白质-蛋白质相互作用。

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

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