We treated 53 patients for male infertility with TSUMURA - Hachimijiogan given as a daily dose of 7.5 g for 144 days on the average. The sperm density was improved by administration to 10 X 10(6)/ml or more in 22 patients (41.5%) and lowered to 10 X 10(6)/ml or more in only 2 patients (3.8%). The sperm motility was improved by 10% or over in 29 patients (54.7%) as compared with 5 patients (9.4%) in whom it was lowered by 10% or more. The sperm motile efficiency index ( SMEI ) was improved in 40 (75.5%) of the 53 patients. Statistically significant differences were noted in the improvement in sperm density, sperm motility and SMEI . By contrast, there was no difference in semen volume, sperm morphology or sperm agglutination between the pre- and post- treatment periods. During the period of treatment, the wives of 4 patients (7.5%) conceived children. These results suggest that TSUMURA - Hachimijiogan is effective for male infertility to a certain extent and that clinical trials on its use for male infertility may be meaningful.
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机译：我们使用TSUMURA-Hachimijiogan治疗了53例男性不育患者，平均每天7.5 g每天服用7.5 g，共144天。 22名患者（41.5％）的精子密度提高到10 X 10（6）/ ml或更高，只有2名患者（3.8％）降低到10 X 10（6）/ ml或更高。 29例患者（54.7％）的精子活力提高了10％或以上，而5例患者（9.4％）的精子活力降低了10％或更多。 53例患者中有40例（75.5％）的精子活动效率指数（SMEI）有所提高。精子密度，精子活力和SMEI的改善在统计学上有显着差异。相反，在治疗前和治疗后期间，精液量，精子形态或精子凝集没有差异。在治疗期间，有4名患者（7.5％）的妻子怀了孩子。这些结果表明，TSUMURA-Hachimijiogan在一定程度上对男性不育症有效，并且关于其用于男性不育症的临床试验可能是有意义的。
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