Biological Study on the Seminal Vesicle 3. The Effects of Various Endocrine Substances on the Seminal Vesicle of the Orchidectomized Guinea-pigs and Dynamic C h anges of the Seminal Vesicle in Mechanical Disturbance of t h e Testis and Spermatic Tubules

摘要

For many years the standard for authorization of sexual hormone has been basedupon the morphological change of the adjutant sexual organs, especially seminal vesicle,of castrated animals to which the hormone has been administered. However, it is notclearified yet that whether the morphological change and development of the seminalvesicle is only influenced by Androgen produced by the testis or the vesicle is directlyaffected by various hormones produced by not only the testis but the hypophysis or theadjutant sexual organs. Even though the development of the seminal vesicle dependsupon hormones produced by the testis, it is again not clearified that the developmentof the vesicle is due whether to circulatory hormone or to the effect of the hormonethrough the spermatic tubules.Author conducted th e following experiment in order to investigate these problems.A) Administration of male hormones (Enarmone de pot, Durotest), go n adtropine(Prehormone, Primogonil), and adrenocortical hormone (Cortone, Interenine) to youngcastrated guinea-pigs resulted in the followings ;1) Male hormones : Significant anti-atrophic action on the seminal vesicle.2) Gonadtropine : No anti-atrophic action on the seminal vesicle.3) Adrenocortical hormones : Among which only Corton e possessed anti-atrophicaction.B) The effects of mechanical disturbances of the testis and spermatic tubules ondynamics of the seminal vesicles are as follows :1) Unilateral orchidectomy did not affect o n the development of the bilateralseminal vesicles.2) B i lateral orchidectomy produced marked atrophy of the bilateral seminal vesicles.3)Bothunilateralandbilateralremovalsofthespermatictubulesdidnotperceivetheabnormalformsintherightorleftsidesofseminalvesiclesandalso,itcouldllotmakeamarkeddifferencebetweenunremovesideandremovalside.