Study of Urinary Calculus Chapter II. Study Pertaining to the Prevention of Urinary Calculus by Means of Vitamin A

摘要

By the insertion of silk thread into the bladder of white rats and rabbits, and by administration of Vitamin A, the cystocalculus formation due to foreign body and the rise and fall of inorganic phosphorus, calcium, magnesium and chlor in serum and urine by administration of same drug were observed. Histological difference of administration and non-administration of Vitamin A to the mucous membrane of the bladder of rats and rabbits was tested. The change of urinary colloid by administering Vitamin A to rabbits and human body in accordance with Yamazoe method was also tested, which results were obtained as follows : 1) Against pho s p horic acid ammonium magnesium calculus in rats, Vitamin A proved to have a remarkable effect on formation-control. 2) Against phosphoric acid cal c ium calculus in rabbits, Vitamin A proved to have no effect on formation-control, on the contrary a slight tendency of formation-acceleration was noted. 3) pH in urine of both rats and rabbits rose higher by administering chocola A. 4) Inorganic phosphorus in rabbits in serum slightly rises by administration o f Vitamin A, but calcium, magnesium and chlor hardly show a change by being administered. 5) By administration of Vitamin A, inorganic phosphorus of rats wa s not changed, and the volume of inorganic phosphorus, calcium and magnesium in urine of rabbits remained unfixed, the effect of Vitamin A was not ascertainable. 6) In regard to histological change of the bl a dder, a fixed difference was not seen between administration and non-administration of Vitamin A to rats, and by administering Vitamin A to rabbits keratinization and inflammatory reaction were restrained.