Studies on the treatment of experimental renal tumors induced by dimethylnitrosamine. II. The effects of cancer chemotherapeutic drugs, such as mitomycin C, 5-fluorouracil and endoxan on experimentally induced renal tumors

摘要

The effects of various cancer chemotherapeutic drugs, such as mitomycin C (MMC), 5-fluorouracil (5-FU) and endoxan on rat kidney tumor induced by feeding dimethylnitrosamine (DMN) were studied. Endoxan injected intraperitoneally showed relative inhibitory effects on the DMN-induced kidney tumors. Histologically, necrotic and edematous changes were found in the kidney tumor tissue in endoxan-treated rats. No inhibitory effects were observed in the groups treated with other drugs.