Gentamicin (GM) was intramuscularly administrated to twenty hospitalized patients with urinary tract infections in the dose of 60 mg x 2/day for 4 to 12 days. Eighteen of them were suffering from complicated infections and the remaining two were suffering from simple infections. Evaluated results were as follows: 1) In 18 patients with complicated infections, clinical effectiveness evaluated by subjective complaints, pyuria and microorganism by urine culture was excellent in 7 (38.9%), good in 4 (22.2%), fair in 11 (61.1%) and poor in 7 (38.9%). In 2 patients with simple infections, clinical effectiveness was excellent in one and good in the other. 2) The most probable predisposable factor of urinary tract infections was the indwelling catheter in the urinary tract. Clinical effectiveness of 8 cases with indwelling catheter was effective in 3 (37.5%) and that of 10 cases without indwelling catheter was effective in 8 (80.0%). 3) In the sensitivity test, GM was active against 6 out of 10 strains of Serratia, 5 out of 7 strains of Pseudomonas, 4 out of 5 Klebsiella, all of 3 strains of Enterobacter, all of 2 strains of Proteus, in total 23 out of 31 strains. 4) No clinical side effect was observed during GM administration in this trial, whereas in the laboratory examination a decrease in PSP was noted in 3 patients, a slight elevation in GOT and GPT in 2, and thrombocytopenia in 1 after GM therapy.
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机译：庆大霉素（GM）以60 mg x 2 /天的剂量肌内给药于20名住院的尿路感染患者，持续4至12天。其中有18名患有复杂的感染，其余两个患有简单的感染。评估结果如下：1）在18例复杂感染患者中，通过主观抱怨，脓尿和尿培养进行的微生物培养评估的临床效果优7例（38.9％），好4例（22.2％），一般11例（61.1） ％）和7（38.9％）的贫困人口。在2例单纯感染患者中，其中一个的临床效果极佳，而另一个则良好。 2）尿路感染的最可能易患因素是尿道内留置导管。有留置导管的8例有效率3例（37.5％），有无留置导管的10例有8例（80.0％）有效。 3）在敏感性试验中，GM对10种沙雷氏菌的6种，7种假单胞菌的5种，5种克雷伯菌的活性，3种肠杆菌，2种变形杆菌都有活性31个菌株中。 4）在该试验中，在施用GM的过程中未观察到临床副作用，而在实验室检查中发现3例患者的PSP降低，GM治疗后GOT和GPT轻度升高2例，血小板减少1例。
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