Aica Orotate, a Nucleic Acid Precursor, in the Treatment of Male Sterility

摘要

AICA orotate (AICAMIN), a nucleic acid precursor, was u sed for the treatment of male sterility. Therapy with AICAMIN in doses of 600 mg/day administered orally was carried out for 4-10 weeks. 1. Of 10 cases of oligozoospermia, 6 showed an increase in sperm counts and 4 were irresponsive to the treatment. Sperm motility was slightly improved in 6 cases. 2. In all 4 cases of azoospermia treated, spermia did not appear in the seminal fluid. 3. Of the 4 cases of necrozoospermia and asthenozoospermia, 1 showed a m oderate increase in motility of the sperm and 3 were irresponsive to the treatment. 4. Five cases of oligozoospermia were treated with a com bination of AICAMIN and gonadotropic hormone preparations. The result was that the number of the sperm increased in all cases. The effect of this agent was remarkable especially in 2 cases. 5. No changes were observed in urinary 17-KS, urinary gonadotropin , and plasma cholesterol values before and after the administration of AICAMIN.