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Histopathological and Histochemical Studies on the Testis of Prostatic Cancer and Prostatic Hypertrophy Report 2 : Experimental Studies on the Effects of Sexual Hormones and of Corticoids upon the Testis

机译:前列腺癌和前列腺肥大的睾丸的组织病理学和组织化学研究报告2:性激素和皮质激素对睾丸影响的实验研究

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摘要

The testicles of white male rabbits which w e ight about 2 kg administrated for 3 weeks synthetic estrogen (Robal 1-2 mg daily. Suron 1-2.5 mg daily), androgen (Enarmon : 2.5 mg daily), corticoids (Cortisone : 12.5 mg daily) were examined histologically and histochemically. The weight of the rabbit testicles decreased markedly when synthetic estrogen or androgen was administrated. The more marked histological and histochemical changes of testicles were observed in the group of the administration of high dosis of estrogen than in the group of small dosis of estrogen. Also, the changes of testicles were almost identical in both group of androgen administration and estrogen. In the cortisone administration, the changes of testicles were almost similar, but relatively slight. In the interstitial cells of Leydig in these rabbits administrated estrogen, androgen and cortisone, any changes were not observed. However, interstitial cell lipids and alkaline phosphatase reaction decreased after the estrogen and androgen administration, but no changes after the cortisone. The 17 ketosteroids in urine decreased after estrogen administration and increased after androgen and cortisone administration. According to the above results, it was presumed that high dosis of the estrogen administration temporarily repressed the androgen secretion from testicles but could not be used in place of castration.
机译:我们将约2公斤的雄性雄性白兔的睾丸注射3周的合成雌激素(每天1-2毫克,苏隆每天1-2.5毫克),雄激素(艾那蒙:每天2.5毫克),皮质激素(可的松:每天12.5毫克) )进行了组织学和组织化学检查。当施用合成雌激素或雄激素时,兔子睾丸的重量显着降低。高剂量雌激素组比小剂量雌激素组的睾丸组织学和组织化学变化更明显。另外,雄激素给药组和雌激素组的睾丸变化几乎相同。在可的松给药中,睾丸的变化几乎相似,但相对较小。在这些给予雌激素,雄激素和可的松的兔子的间质细胞中,未观察到任何变化。然而,雌激素和雄激素给药后,间质细胞脂质和碱性磷酸酶反应降低,但在可的松后无变化。服用雌激素后尿液中的17种酮类固醇减少,而服用雄激素和可的松后尿中的17种酮类固醇增加。根据上述结果,推测高剂量的雌激素给药可暂时抑制睾丸中雄激素的分泌,但不能代替去势。

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    小山 勇;

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  • 年度 1960
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  • 原文格式 PDF
  • 正文语种 ja
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