Objective: To examine microcystic inner nuclear layer (INL) changes in glaucomatous eyes and to determine associated factors. Design: Retrospective, cross-sectional, observational study. Methods: Two hundred seventeen eyes of 133 patients with primary open angle glaucoma (POAG), 41 eyes of 32 patients with preperimetric glaucoma and 181 normal eyes of 117 subjects were ultimately included. Microcystic INL lesions were examined with infrared fundus images and with 19 vertical spectral domain optical coherence tomography (SD-OCT) images in the macular area. Results: Microcystic INL changes were observed in 6. 0% of eyes with POAG, but none of the normal eyes or eyes with preperimetric glaucoma showed microcystic INL changes. The proportion of eyes with advanced glaucoma was significantly larger (P = 0. 013) in eyes with microcystic lesions than without. The visual field mean deviation (MD) slope was also significantly worse (P = 0. 027) in eyes with microcystic lesions. No significant differences were observed in age, sex, refraction, axial length, intraocular pressure, or MD value between eyes with and without microcystic INL lesions. In several cases, microcystic INL lesions occurred along with glaucomatous visual field progression. The retinal nerve fiber layer (RNFL) thickness (P = 0. 013) and ganglion cell layer (GCL) + inner plexiform layer thickness (P = 0. 023) were significantly lower in areas with microcystic lesions than without. The INL was also significantly thicker (P = 0. 002) in areas with microcystic lesions. Conclusions: Microcystic INL lesions in glaucomatous eyes are closely associated with RNFL and GCL thinning and correlated with worse MD slope. These INL lesions may indicate focal and progressive damage in glaucoma.
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