Clinical studies of male sterility Part II : Observation of testicular histology

摘要

Testicular biopsy was performed in 115 cases out of 172 w ith male infertility visited the urological clinic of Osaka Medical College. Examination of their semen showed 81 azoospermia , 30 oligozoospermia, 3 aspermia and 1 necrozoospermia. Biopsy specimens were histologically studied and classified to five groups on the changes of seminiferous tubules with following incidence in each. I. Germ cell aplasia 19.1% II. Spermatogenic arrest 13 . 9 % III. Hypospermatogenesis 3 4 . 8% IV. Peritubular or tubular fibrosis 19 . 1 % V. Normal 1 3.1% Testicular biopsy findings were also classified according to the cha n ges both of the seminiferous tubules and interstitial tissue as follows. A. Lesion in seminiferous tubules o n l y 17.4% B. Lesion in interstitial tissue only 1 . 7 % C. Lesion in both 7 1 . 3% D. Normal in both 9 .6% Cases with azoospermia and oligozoospermia were accordingly classified with following results. Azoospermia Oligozoospermia I 27.2(%) 0 (%) II 19.7 0 III 19.7 7 3.3 IV 24.7 6 . 7 ^ 8.7 2 0 . 0 A 14.8(%) 2 3 . 3 (%) B 0 6.7 C 77.8 6 0.0 D 7.4 10.0 Physical examinations of the testes, epididymes and prostate were also described with regard to biopsy findings of the testes. Interesting cases were demonstrated with review of literatures. They are two cases with similar histology to that of so-called fertile eunuchs in which lesion is limited only in the stroma, and another with intratubular body, calculus formed in the seminiferous tubule.