THE EFFECT OF NEUROPHARMACOLOGIC AGENTS UPON BLADDER AND URETHRA: PROSTAGLANDIN,PARASYMPATHOLYTICS AND ALPHA ADRENERGIC BLOCKADE

摘要

The effect of neuropharmacologic agents upon the function of bladder and urethra has been investigated. Prostaglandins (PGs) were intravenously given to female mongrel dogs to evaluate their potencies to evacuate the urine. PGE series were found superior to PGF2α to accomplish an efficient voiding, while PGA, was of no effect. The result of prostaglandin test in men was in accord with that of Lapides-Glahn test. That is, the chronically denervated bladder responded to PG995 with a similar supersensitivity. It is certain that PGs play an important role for the contractile mechanism of bladder. Parasympatholytics were of effect to suppress an uninhibited bladder contraction found in an unstable bladder. In order to evaluate the bladder function cystometrically, the provocation procedure is essential, otherwise one third of cases might be erronously diagnosed. Autonomic hyperreflexia found in patients with lesion of the neuraxis above the 7th dorsal segment was assessed by the administration of phentolamine, an alpha adrenergic blockade. One should be cautious to prevent this syndrome by excluding the extensive nociceptive and proprioceptive stimuli upon the urinary bladder.