SERUM LEVELS OF CEFSULODIN AND CEFOTIAM DURING BLOOD PURIFICATION IN UREMIC PATIENTS

摘要

The serum levels of Cefsulodin and Cefotiam, new semisynthetic cepharosporines, in uremic patients were determined during blood purification. Cefsulodin was given in a single intravenous dose of 0.5g to uremic patients before blood purification. Serum levels were 12.3-32.3 mcg/ml after 30 minutes, 7.2-17.6 mcg/ml after 2 hours and 3.4-8.9 mcg/ml after blood purification. The half-life of Cefsulodin during hemodialysis, hemodiafiltration and hemofiltration was 3.05 hours, 1.37 hours and 2.28 hours respectively. Cefotiam was given by the same method as Cefsulodin to uremic patients before blood purification. Serum levels were 23.2-49.7 mcg/ml after 30 minutes, 13.4-20.0 mcg/ml after 2 hours and 5.9-10.0 mcg/ml after blood purification. The half-life of Cefotiam during hemodialysis, hemodiafiltration and hemofiItration was 1.85 hours and 1.23 hours and 2.13 hours, respectively. These two new antibiotics were well dialysed or filtrated by .blood purification.