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A novel cell-to-cell trafficking assay indicates that the KNOX homeodomain is necessary and sufficient for intercellular protein and mRNA trafficking

机译:一种新颖的细胞间运输试验表明,KNOX同源结构域对于细胞间蛋白质和mRNA的运输是必要和充分的

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摘要

Cell-to-cell trafficking of regulatory proteins is a novel mechanism for communication during cell fate specification in plants. Although several developmental proteins traffic cell-to-cell, no signals that are both necessary and sufficient for this function in developmental proteins have been described. We developed a novel trafficking assay using trichome rescue in Arabidopsis. Fusion to KNOTTED1 (KN1) conferred gain-of-trafficking function to the cell-autonomous GLABROUS1 (GL1) protein. We show that the KNOX homeodomain (HD) is necessary and sufficient for intercellular trafficking, identifying a novel function for the HD as the minimal sequence required for trafficking of KN1 and its associated mRNA.
机译:细胞间调节蛋白的运输是一种在植物细胞命运指定期间进行通讯的新机制。尽管几种发育蛋白在细胞之间运输,但尚未描述在发育蛋白中为此功能所必需和足够的信号。我们开发了一种在拟南芥中使用毛状体营救的新型贩运检测方法。与KNOTTED1(KN1)的融合赋予了细胞自主GLABROUS1(GL1)蛋白贩运功能。我们表明,KNOX同源域(HD)是必要和足够的细胞间贩运,确定HD的新功能作为贩运KN1及其相关mRNA所需的最小序列。

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