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Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns

机译:大鼠体感皮层2/3层锥体神经元轴突柄的关键时期可塑性:剥夺皮层的特定层投影减少

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摘要

We examined the effect of whisker trimming during early postnatal development on the morphology of axonal arbors in rat somatosensory cortex. Axonal arbors from populations of layer 2/3 pyramidal neurons in the D2 column were labeled by lentivirus-mediated expression of green fluorescent protein. Axonal projection patterns were compared between untrimmed control animals and animals with all whiskers in A-, B-, and C-rows trimmed (D- and E-rows left intact) from postnatal days 7 to 15 (termed from here on DE-pairing). Control animals had approximately symmetrical horizontal projections toward C- and E-row columns in both supra- and infragranular layers. Following DE-pairing, the density of axons in supragranular layers projecting from the labeled neurons in the D2 column was higher in E- than in C-row columns. This asymmetry resulted primarily from a reduction in projection density toward the deprived C-row columns. In contrast, no change was observed in infragranular layers. The results indicate that DE-pairing during early postnatal development results in reduced axonal projection from nondeprived into deprived columns and that cortical neurons are capable of structural rearrangements at subsets of their axonal arbors.
机译:我们检查了出生后早期发育过程中晶须修整对大鼠体感皮层轴突轴的形态的影响。通过慢病毒介导的绿色荧光蛋白表达标记D2列第2/3层锥体神经元群体的轴突。比较了未修剪的对照动物和从出生后第7天到第15天修剪了A行,B行和C行的所有晶须(完整保留D行和E行)的轴突投影模式(在此处称为DE配对) )。对照动物在上​​层和下层中都向C行和E行列具有近似对称的水平投影。在DE配对后,从D2列中标记的神经元突出的颗粒上层中轴突的密度在E-中高于在C行中。这种不对称性主要是由于朝向缺乏的C行列的投影密度降低所致。相反,在颗粒下层中未观察到变化。结果表明,在产后早期发育阶段,DE配对导致轴突投射从非剥夺列变为剥夺列,并且皮质神经元能够在其轴突柄亚集处进行结构重排。

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