首页> 外文OA文献 >Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories.
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Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories.

机译:环境富集和隔离住房对成年大鼠前额叶皮层应激的激素和神经化学反应的不同影响:与工作和情绪记忆的关系。

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摘要

The present study was designed to investigate the modulation of the stress responses by the environmental conditions and its putative neurobiological mechanisms. For that an integrative study on the effects of environmental enrichment and isolation housing on (1) the corticosterone, dopamine and acetylcholine responses to acute restraint stress in the prefrontal cortex (PFC) of the awake rat; (2) the mRNA levels of glucocorticoid receptors (GRs) in the PFC, and (3) the behavioral responses to stress, related to the PFC (habituation to a novel environment, spatial-working memory and inhibitory avoidance response) was performed. Male Wistar rats were maintained from 3 to 6 months of age in two different conditions: enriched (EC) or impoverished (IC). Animals were stereotaxically implanted with bilateral guide cannulae in the PFC to perform microdialysis experiments to evaluate the concentrations of corticosterone, dopamine and acetylcholine. EC animals showed lower increases of corticosterone and dopamine but not of acetylcholine than IC animals in the PFC in response to acute restraint stress (20 min). In the PFC, GR mRNA levels showed a trend towards an enhancement in EC animals. EC reduced the days to learn the spatial working memory task (radial-water maze). Spatial working memory, however, was not different between groups in either basal or stress conditions. Inhibitory avoidance response was reduced in EC rats. The changes produced by EC in the neurochemical, neuroendocrine and behavioral parameters evaluated suggest that EC rats could show a better coping during an acute stress challenge.
机译:本研究旨在研究环境条件及其可能的神经生物学机制对应激反应的调节作用。为此,对环境富集和隔离环境对(1)清醒大鼠前额叶皮层(PFC)中的皮质酮,多巴胺和乙酰胆碱对急性束缚应激反应的影响进行了综合研究; (2)进行了PFC中糖皮质激素受体(GRs)的mRNA水平,以及(3)与PFC有关的对应激的行为反应(对新环境的适应,空间工作记忆和抑制回避反应)。 Wistar雄性大鼠在两种不同的条件下维持3到6个月大:富营养(EC)或贫困(IC)。将动物的双侧引导套管立体定位植入PFC中,以进行微透析实验,以评估皮质酮,多巴胺和乙酰胆碱的浓度。响应急性束缚应激(20分钟),在PFC中,EC动物的皮质酮和多巴胺的增加量低于IC动物,而乙酰胆碱的增加量则没有。在PFC中,GR mRNA水平在EC动物中呈增加趋势。 EC减少了学习空间工作记忆任务(radi水迷宫)的时间。但是,在基础或压力条件下,两组之间的空间工作记忆没有差异。 EC大鼠的抑制回避反应减少。 EC在神经化学,神经内分泌和行为参数评估中产生的变化表明,EC大鼠在急性应激挑战期间可能表现出更好的应对能力。

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