A study on dynamical properties of the force exerted by lamellipodia and filopodia using optical tweezers

摘要

During neuronal differentiation, lamellipodia and filopodia explore the environment in search for the correct path to the axon's final destination. Although the motion of lamellipodia and filopodia has been characterized to an extent, little is known about the force they exert. In this study, we used optical tweezers to measure the force exerted by filopodia and lamellipodia of dorsal root ganglia (DRG) neurons.