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Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds

机译:微乳液电动色谱法适合用于测定酸性,中性和碱性化合物的亲脂性

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摘要

In the present work, several MEEKC systems are studied to assess their suitability for lipophilicity determination of acidic, neutral, and basic compounds. Thus, several microemulsion compositions over a wide range of pH values (from 2.0 to 12.0), containing heptane, 1−butanol and different types and amounts of surfactant (SDS or sodium cholate: from 1.3 to 3.3%) are characterized using Abraham's solvation model. The addition of acetonitrile (up to 10%) is also studied, since it increases the resolution of the technique for the most lipophilic compounds. The system coefficients obtained are very similar to those of the 1−octanol/water, used as the reference lipophilicity index, allowing simple and linear correlations between the 1−octanol/water partition values (log Po/w) and MEEKC mass distribution ratios (log kMEEKC). Variations in the microemulsion composition (aqueous buffer, surfactant, concentration of ACN) did not significantly affect the similarity of the MEEKC systems to log Po/w partition.
机译:在目前的工作中,研究了几种MEEKC系统,以评估其对酸性,中性和碱性化合物的亲脂性测定的适用性。因此,使用亚伯拉罕的溶剂化模型表征了几种在宽pH值范围(2.0至12.0)内的微乳液组合物,其中包含庚烷,1-丁醇和不同类型和数量的表面活性剂(SDS或胆酸钠:1.3至3.3%)。 。还研究了乙腈(最多10%)的添加,因为它可以提高大多数亲脂性化合物的分离度。获得的系统系数与1-辛醇/水的系统系数非常相似,用作参考亲脂性指数,从而允许1-辛醇/水分配值(log Po / w)与MEEKC质量分布比之间的简单线性相关性(日志kMEEKC)。微乳液组成的变化(水性缓冲液,表面活性剂,ACN的浓度)不会显着影响MEEKC系统对Po / w分配的相似性。

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