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Characterization of the outer membrane subproteome of the virulent strain Salmonella Typhimurium SL1344

机译:的外膜亚蛋白质组的表征 强毒株鼠伤寒沙门氏菌SL1344

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摘要

Outer membrane proteins (OMPs) play an important role in the interaction of bacterial pathogens with host cells. Indeed, some OMPs from different Gram-negative bacteria have been recognized as important virulence factors for host immune recognition. This scenario has led to the study of the outer membrane (OM) subproteome of pathogenic bacteria as an essential step for gaining insight into the mechanisms of pathogenesis and for the identification of virulence factors. Although progress in the characterization of the OM has recently been reported, detailed protein composition of this subcellular localization has not been clearly defined for most pathogens. Salmonella enterica serovar Typhimurium is not only a leading cause of human gastroenteritis in high-income countries but is also one of the main causes of invasive non-typhoidal salmonellosis (iNTS) in middle- and low-income countries. The incidence of non-typhoidal salmonellosis is increasing worldwide, causing millions of infections and deaths among humans each year. Regrettably, antimicrobial resistance to a broad spectrum of antibiotics is common among non-Typhi Salmonella strains. Therefore, the development of vaccines targeting this leading invasive pathogen is warranted. In the present study we have identified the OM protein profile of the virulent S. Typhimurium strain SL1344 by means of sarkosyl extraction.
机译:外膜蛋白(OMP)在细菌病原体与宿主细胞的相互作用中起重要作用。实际上,一些来自不同革兰氏阴性细菌的OMP已被认为是宿主免疫识别的重要毒力因子。这种情况已导致对病原细菌的外膜(OM)子蛋白质组的研究,作为深入了解发病机理和鉴定毒力因子的重要步骤。尽管最近已经报道了OM表征的进展,但是对于大多数病原体,尚未明确定义这种亚细胞定位的详细蛋白质组成。肠炎沙门氏菌鼠伤寒沙门氏菌不仅是高收入国家人类胃肠炎的主要原因,而且还是中低收入国家侵袭性非伤寒沙门氏菌病(iNTS)的主要原因之一。在世界范围内,非伤寒沙门氏菌病的发病率正在上升,每年在人类中造成数百万的感染和死亡。遗憾的是,非伤寒沙门氏菌菌株对多种抗生素具有抗药性。因此,有必要开发针对这种主要侵入性病原体的疫苗。在本研究中,我们已经通过鼠李糖基提取法鉴定了强毒鼠伤寒沙门氏菌菌株SL1344的OM蛋白谱。

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