Doppelt-aktivierte S-Adenosyl-L-Methionin-Analoga mit funktionalisierten Seitenketten zur sequenzspezifischen Übertragung durch DNA-Methyltransferasen

摘要

In this thesis, the analouges AdoBenz, AdoBenz4Me, AdoFurfuryl, AdoDis and AdoEnIn of the natural methylgroupdonor S-Adenosyl-L-Methionin (AdoMet) were synthezised and tested for their reactivity in DNA-methyltransferase catalyzed reactions.