Zur asymmetrischen Synthese von Vaginidiol, Smyrindiol und Euonidiol, sowie über die stereoselektive Synthese von 2,3-Dihydroindol- und 2,3-Dihydrobenzofuran-Derivaten

摘要

In this work the asymmetric synthesis of the natural products Vaginidiol, Euonidiol and Smyrindiol was investigated using an organocatalytic, intramolecular aldol reaction as key step. Furthermore it was elaborated to extend the aldol reaction to the synthesis of dihydroindoles and dihydrothiophenes. In addition different Michael-acceptors such as nitroalkenes and unsaturated esters were tested successfully in an organocatalytic 5-enolexo cyclisation reaction.