How Pure is Pure? Metal Complexation Studies Directed Towards Pharmaceutical Drug Purification

摘要

Catalytic processes play critical roles in the modern-day industrial syntheses of many commonplace materials such as plastics, fuel production, electronics, and pharmaceuticals. Transition metal catalysts may become homogeneously embedded within solid nanomaterials during their synthetic scheme, which can result in deleterious effects on both the construction and durability of the material as well as its intended functionality.Traditional purification methods of these materials rely upon harsh reaction conditions that may either affect or allow for specific functionalities. Arylazothioformamide (ATF) ligands have proven to be a mild alternative for their ability to chelate these solid transition metal catalysts.This work will describe the synthetic steps towards developing a versatile library of ATF ligands, the characterization of those already synthesized, and initial chelation studies directed towards the purification of pharmaceutical drugs which employ catalytic processes in their production.