Studies on pathogenesis and treatment of experimental immune complex glomerulonephrtis.

摘要

Chapter 1. In this thesis an investigation into pathogenetic mechanisms of epimembranous immune complex depostion in the glomeruli was described. For this study we used two related models of experimental immune complex glemerulonephritis: the heterologous and the autologous immune complex glomerulonephritis. The "natural history" of these two models was compared and the effect of some factors which influenced the deposition of immune complexes in the GBM were studied. These factors were: 1. a treatment with a combination of immunosuppressive drugs and prednisolone. 2. injections of the constituents of immune complexes, i.e. antigen or antibody. 3. an induction of increased permeability of the GBM by aminonucleoside of puromycin.... Zie: Summary