首页> 外文OA文献 >Group II metabotropic glutamate (mGlu2/3) receptors:potential drug targets for the treatment of schizophrenia and anxiety?

【2h】

Group II metabotropic glutamate (mGlu2/3) receptors:potential drug targets for the treatment of schizophrenia and anxiety?

机译：II组代谢型谷氨酸（mGlu2 / 3）受体：治疗精神分裂症和焦虑症的潜在药物靶点？

页面导航

摘要
著录项
相似文献
相关主题

摘要

Glutamaat is de belangrijkste stimulerende neurotransmitter in het centrale zenuwstelsel van de mens. Het aminozuur is betrokken bij bijna alle aspecten van het functioneren van de hersenen, zoals cognitie, leren en geheugen. Het laatste decennium worden glutamaat receptoren naar voren geschoven als potentiële therapeutische doelen voor geneesmiddelen voor een scala van psychiatrische stoornissen, waaronder schizofrenie en angst/stress-stoornissen.

机译：谷氨酸是人类中枢神经系统中主要的刺激性神经递质。氨基酸几乎参与大脑功能的所有方面，例如认知，学习和记忆。在过去的十年中，谷氨酸受体已被推向许多精神疾病的潜在药物治疗靶点，包括精神分裂症和焦虑/压力障碍。

著录项

作者
Imre Gábor;
展开▼
作者单位

展开▼
年度 2006
总页数
原文格式 PDF
正文语种 eng
中图分类

相似文献

外文文献
中文文献
专利

1. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. [J] . Caraci F, Molinaro G, Battaglia G, Molecular pharmacology. . 2011,第3期

机译：靶向II型代谢型谷氨酸（mGlu）受体用于治疗与阿尔茨海默氏病相关的精神病：mGlu2受体的选择性激活会放大培养的神经元的β-淀粉样蛋白毒性，而mGlu2和mGlu3受体的双重激活具有神经保护作用。
2. The metabotropic glutamate receptors: Potential drug targets for the treatment of anxiety disorders? [J] . Nikolaos Pitsikas European Journal of Pharmacology: An International Journal . 2014,第Null期

机译：代谢型谷氨酸受体：用于治疗焦虑症的潜在药物靶标吗？
3. Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia [J] . Francesco Fazio, Luana Lionetto, Martina Curto, Scientific reports. . 2015,第1期

机译：黄原酸激活mGlu2 / 3代谢型谷氨酸受体，是精神分裂症的潜在特征标记
4. Manifold learning visualization of Metabotropic Glutamate Receptors [C] . Martha-Ivon Cardenas, Alfredo Vellido, Jesus Giraldo International Conference of the Catalan Association for Artificial Intelligence . 2014

机译：代谢谷氨酸受体的歧管学习可视化
5. Metabotropic glutamate receptors as targets for antiepileptic drug therapy: A behavioral and electroencephalographic analysis. [D] . Caulder, Erin H. 2013

机译：代谢型谷氨酸受体作为抗癫痫药物治疗的靶标：行为和脑电图分析。
6. Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia [O] . Francesco Fazio, Luana Lionetto, Martina Curto, -1

机译：黄原酸激活mGlu2 / 3代谢型谷氨酸受体是精神分裂症的潜在特征标记
7. Metabotropic glutamate receptor 3 neuroprotection A. Berent-Spillson and J. W. Russell Received June 12, 2006; revised manuscript received October 3, 2006; accepted October 5, 2006. Address correspondence and reprint requests to James W. Russell, Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201-1595, USA. E-mail: jruss@umich.edu Abbreviations used : APDC , 2 R ,4 R -4-aminopyrrolidine-2,4-dicarboxylate (specific metabotropic glutamate receptor 3 agonist) ; BSO , buthionine sulfoximine (GSH synthesis inhibitor) ; caspase , cysteine-requiring aspartate protease ; CysGly , cysteinylglycine (GSH degradation product) ; DAPI , 4′-6-diamidino-2-phenylindole ; DCF , dichlorodihydrofluorescein ; DCFDA , 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester ; DHE , dihydroethidium ; DRG , dorsal root ganglion ; FCCP , carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (electron transport uncoupler) ; GCP II/III , glutamate carboxypeptidase II/III ; GSH , glutathione ; GSH-EE , glutathione ethyl ester ; GST , glutathione-s-transferase ; H 2 O 2 , hydrogen peroxide ; HBSS , Hank’s balanced salt solution ; JC-1 , 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide ; MCB , monochlorobimane ; mGluR , metabotropic glutamate receptor ; NAAG , N -acetyl-aspartyl-glutamate ; PBS , phosphate-buffered saline ; PCD , programmed cell death ; Rh123 , rhodamine123 ; ROS , reactive oxygen species ; δψ μ , inner mitochondrial membrane potential . Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration [O] . Berent-Spillson Alison, Russell James W. 2007

机译：代谢型谷氨酸受体3神经保护a. Berent-spillson和J. W. Russell于2006年6月12日收到;修订稿于2006年10月3日收到; 2006年10月5日接受。美国马里兰州巴尔的摩市南格林街22号，马里兰大学医学院神经病学系James W. Russell的地址通信和重印申请。电子邮件：jruss@umich.edu使用的缩写：apDC，2R，4R-4-氨基吡咯烷-2,4-二羧酸酯（特异性代谢型谷氨酸受体3激动剂）; BsO，丁硫氨酸亚砜亚胺（GsH合成抑制剂）;半胱天冬酶，半胱氨酸需要的天冬氨酸蛋白酶; CysGly，半胱氨酰甘氨酸（GsH降解产物）; DapI，4'-6-二脒基-2-苯基吲哚; DCF，二氯二氢荧光素; DCFDa，5-（和6） - 氯甲基-2'，7'-二氯二氢荧光素二乙酸酯，乙酰酯; DHE，二氢乙锭; DRG，背根神经节; FCCp，羰基氰化物4-（三氟甲氧基）苯腙（电子传输解偶联剂）; GCp II / III，谷氨酸羧肽酶II / III;谷胱甘肽;谷胱甘肽; GsH-EE，谷胱甘肽乙酯; GsT，谷胱甘肽-s-转移酶; H 2 O 2，过氧化氢; HBss，Hank的平衡盐溶液; JC-1,5,5'，6,6'-四氯-1,1'，3,3'-四乙基苯并咪唑基酞菁碘化物; mCB，monochlorobimane; mGluR，代谢型谷氨酸受体; NaaG，N-乙酰基 - 天冬氨酰谷氨酸; pBs，磷酸盐缓冲盐水; pCD，程序性细胞死亡; Rh123，罗丹明123;活性氧，活性氧; δψμ，线粒体内膜电位。代谢型谷氨酸受体3通过增加细胞内谷胱甘肽浓度来保护神经元免受葡萄糖诱导的氧化损伤
8. Group II Metabotropic Glutamate Receptors as Potential Pharmaceutical Targets for Neurofibroma Formation [R] . Stern, M. 2011

机译：第II组代谢型谷氨酸受体作为神经纤维瘤形成的潜在药物靶标

Group II metabotropic glutamate (mGlu2/3) receptors:potential drug targets for the treatment of schizophrenia and anxiety?

摘要

著录项

相似文献

相关主题

期刊订阅