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Comparative evaluation of anti microbial effects of triple antibiotic paste and amox and its derivatives against E. Faecalis : an in vitro study

机译:三种抗生素糊剂和阿莫克斯及其衍生物对屎肠球菌的抗微生物作用的比较评价:体外研究

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摘要

Enterococcus faecalis is a microorganism commonly detected in asymptomatic, persistent endodontic infections. Triple antibiotic paste has stood the test of time as a proven antibiotic combination against E. Faecalis. However, problems with this include staining of teeth and standardization of the preparation. Thus, the search for better alternatives and better preparation techniques is still on. To observe the potential of combinations [(Amoxicillin+ Metronidazole, Amoxicillin Clavulanic Acid + Metronidazole; Amoxicillin and Cloxacillin + Metronidazole)] over Triple Antibiotic Paste. Fifty single rooted teeth free from dental caries were selected for the study. Teeth were cut at equal distance from root apex (13mm from apex) with sterile diamond disk and straight hand piece for standardization of root length. The opening of root canal was enlarged with engine driven pro-taper files. To remove the organic and inorganic debris, canal was cleaned with 17% EDTA followed by 2.5% NaOCl for 5min. Distilled water irrigation was done for 5 min to remove any traces of used chemical and then sterilized in autoclave at 1200c for 15 min. at 15 lbs pressure. Bacteria cultured on blood agar plate and at the same time fresh antibiotic combinations were made and placed in the root canals, then incubated in the incubator, under sterile conditions and observed at 24hrs, 48hr and 72hrs. The largest inhibition zones were observed for the Triple Antibiotic Paste, followed by Amoxicillin and Clavulanic acid + Metronidazole group however, the clearest zones were achieved with Amoxicillin and Clavlunic acid + Metronidazole group and the smallest for Amoxicillin and Metronidazole group. The results suggest that though Triple antibiotic showed the maximum inhibition, Amoxicillin and Clavulanic acid combination along with Metronidazole gave the most reliable results. Further studies using the different combinations and different concentrations along with different methods of increasing the shelf life of such medications can be undertaken.
机译:粪肠球菌是一种在无症状,持续性牙髓感染中常见的微生物。三重抗生素糊剂已被证明是对抗屎肠球菌的抗生素组合,经受了时间的考验。但是,与此相关的问题包括牙齿的染色和制剂的标准化。因此,仍在寻找更好的替代品和更好的制备技术。观察三联抗生素糊剂上的组合[(阿莫西林+甲硝唑,阿莫西林克拉维酸+甲硝唑;阿莫西林和氯西林+甲硝唑)]的潜力。选择五十只无牙龋的单根牙齿用于该研究。用无菌金刚石盘和笔直的手柄将牙齿从根尖等距切开(距顶点13mm),以标准化根长。用发动机驱动的锥形锉刀扩大了根管的开口。为了去除有机和无机碎屑,先用17%EDTA,然后用2.5%NaOCl清洁运河5分钟。进行蒸馏水冲洗5分钟,以除去任何痕量的用过的化学药品,然后在1200℃的高压釜中灭菌15分钟。在15磅压力下。在血琼脂平板上培养细菌,同时制备新鲜的抗生素组合并将其置于根管中,然后在无菌条件下在培养箱中孵育,并在24小时,48小时和72小时观察。在三重抗生素糊剂中观察到最大的抑制区,其次是阿莫西林和克拉维酸+甲硝唑组,但是,阿莫西林和克拉维酸+甲硝唑组的抑制区最清晰,而阿莫西林和甲硝唑的组则最小。结果表明,尽管三重抗生素显示出最大的抑制作用,但阿莫西林和克拉维酸联合甲硝唑的组合提供了最可靠的结果。可以进行使用不同组合和不同浓度以及增加此类药物保质期的不同方法的进一步研究。

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