首页> 外文OA文献 >AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

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AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

机译：AAV1 / 2诱导的黑质中A53T-α-突触核蛋白过表达导致黑质纹状体系统变性，并伴有路易氏病和运动障碍：帕金森氏病的新小鼠模型

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1. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease [J] . Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari, Acta Neuropathologica Communications . 2017,第1期

机译：AAV1 / 2诱导的黑质中A53T-α-突触核蛋白过表达导致黑质纹状体系统变性，并伴有路易氏病和运动障碍：帕金森氏病的新小鼠模型
2. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pat [J] . James B Koprich, Tom H Johnston, M Gabriela Reyes, Molecular neurodegeneration . 2010,第1期

机译：使用新型AAV1 / 2载体在大鼠黑质中表达人A53Tα-突触核蛋白可产生迅速发展的病理学，并伴有蛋白聚集，营养不良的神经突结构和黑质纹状体变性，可能会模拟拍打
3. Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-alpha-synuclein-A53T mouse model, correlating with increased nitration and aggregation of alpha-synuclein and exacerbation of motor impairment [J] . Maki Richard A., Holzer Michael, Motamedchabok Khatereh, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2019,第期

机译：人体髓氧化酶（HMPO）在帕金森病的Imageia nigRa中的神经元中表达，并在HMPO-α-突触核蛋白-A53T小鼠模型中，与α-突触核蛋白的零核苷酸增加和聚集进行相关性和电机损伤的加剧
4. Evaluation of A Rat Model of Parkinson's Disease by Injection of 6-OHDA into The Substantia Nigra [C] . Jian Mao, Wei Yang, Ran Wang, 2007 IEEE/ICME INTERNATIONAL CONFERENCE ON COMPLEX MEDICAL ENGINEERING . 2007

机译：通过将6-OHDA注入黑质中评估帕金森氏病大鼠模型
5. The Temporal Relationship between Synucleinopathy, Nigrostriatal Degeneration, and Neuroinflammation in the Alpha-Synuclein Preformed Fibril Model of Parkinson's Disease [D] . Duffy, Megan Frances. 2018

机译：帕金森氏病的α-突触核蛋白预制的原纤维模型中突触核蛋白病，纹状体变性和神经炎症之间的时间关系。
6. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease [O] . Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari, 2017

机译：AAV1 / 2诱导的黑质中A53T-α-突触核蛋白过表达导致黑质纹状体系统变性并伴有路易氏病和运动障碍：帕金森氏病的新小鼠模型
7. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease [O] . James B Koprich, Tom H Johnston, M Gabriela Reyes, 2010

机译：使用新型AAV1 / 2载体在大鼠黑质中表达人A53Tα-突触核蛋白可产生迅速发展的病理学，并伴有蛋白质聚集，营养不良的神经突结构和黑质纹状体变性，具有模拟帕金森氏病病理学的潜力

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

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