首页> 外文OA文献 >QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

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QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

机译：QLT0267是靶向整联蛋白连接激酶（ILK）的小分子抑制剂，与多西紫杉醇结合使用可产生协同相互作用，从而增强原位乳腺癌模型的细胞毒性，降低P-AKT水平，改变F-肌动蛋白结构并改善治疗效果

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Jessica Kalra; Corinna Warburton; Karen Fang; Lincoln Edwards; Tim Daynard; Dawn Waterhouse; Wieslawa Dragowska; Brent W Sutherland; Shoukat Dedhar; Karen Gelmon; Marcel Bally;
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1. QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outc [J] . Jessica Kalra, Corinna Warburton, Karen Fang, Breast Cancer Research . 2009,第3期

机译：QLT0267是靶向整合素连接激酶（ILK）的小分子抑制剂，与多西紫杉醇结合使用可产生协同相互作用，从而增强细胞毒性，降低P-AKT水平，改变F-actin结构并改善治疗效果
2. QLT0267 a small molecule inhibitor targeting integrin-linked kinase (ILK) and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity reductions in P-AKT levels altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model [O] . Jessica Kalra, Corinna Warburton, Karen Fang, 2009

机译：QLT0267是靶向整联蛋白连接激酶（ILK）的小分子抑制剂与多西紫杉醇结合使用可产生协同相互作用从而增强原位乳腺癌模型的细胞毒性降低P-AKT水平改变F-肌动蛋白结构并改善治疗效果
3. QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model [O] . Kalra, Jessica, Warburton, Corinna, Fang, Karen, 2009

机译：QLT0267是靶向整联蛋白连接激酶（ILK）的小分子抑制剂，与多西紫杉醇结合使用可产生协同相互作用，从而增强原位乳腺癌模型的细胞毒性，降低P-AKT水平，改变F-肌动蛋白结构并改善治疗效果

QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

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