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A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

机译：数字基因组扫描是一种检测胃癌中KRAS基因扩增的新方法：过表达的野生型KRAS参与下游信号传导和癌细胞生长

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Hiroaki Mita; Minoru Toyota; Fumio Aoki; Hirofumi Akashi; Reo Maruyama; Yasushi Sasaki; Hiromu Suzuki; Masashi Idogawa; Lisa Kashima; Kazuyoshi Yanagihara; Masahiro Fujita; Masao Hosokawa; Masanobu Kusano; Sorin Vasile Sabau; Haruyuki Tatsumi; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino;
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1. Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. [J] . Takezawa K, Okamoto I, Yonesaka K Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第16期

机译：索拉非尼通过靶向KRAS野生型细胞中的B-RAF和KRAS突变细胞中的C-RAF来抑制非小细胞肺癌细胞的生长。
2. Whole Genome Gene Copy Number Profiling of Gastric Cancer Identifies PAKI and KRAS Gene Amplification as Therapy Targets [J] . Ziliang Qian, Guanshan Zhu, Lili Tang, Genes, Chromosomes and Cancer . 2014,第11期

机译：胃癌全基因组基因拷贝数分析确定了PAKI和KRAS基因扩增为治疗靶标
3. Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS. [J] . Furugaki K, Iwai T, Shirane M, Oncology reports . 2010,第5期

机译：与埃洛替尼和多西他赛联合使用对人非小细胞肺癌细胞具有EGFR突变，KRAS突变或野生型EGFR和KRAS的时间表依赖性抗肿瘤活性。
4. L-Ascorbic Acid Can Abrogate X Gene-Dependent Cetuximab Resistance Mediated by Mutant KRAS in Human Colon Cancer Cells [C] . Soo-A Jung, Jai-Hee Moon, Ih Yeon Hwang, International Molecular Medicine Tri-Conference. . 2016

机译：L-抗坏血酸可以消除突变克拉斯在人结肠癌细胞中介导的X基因依赖性的辛酸抗性
5. Genetic and environmental influences on the mutational landscape of Kras-driven lung cancer in the mouse. [D] . Westcott, Peter Maxwell Kienitz. 2015

机译：遗传和环境对小鼠Kras驱动的肺癌的突变景观的影响。
6. Increased mutant KRAS gene dosage drives pancreatic cancer progression: evidence for wild-type KRAS as a tumor suppressor? [O] . Oliver A. Kent 2018

机译：突变KRAS基因剂量的增加驱动胰腺癌的发展：野生型KRAS作为抑癌药的证据？
7. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth [O] . Mita, Hiroaki, Toyota, Minoru, Aoki, Fumio, 2009

机译：数字基因组扫描是一种检测胃癌中KRAS基因扩增的新方法：过表达的野生型KRAS参与下游信号传导和癌细胞生长
8. Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6 for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia. Technology Assessment Report [R] . Terasawa, T., Dahabreh, I., Castaldi, P. J., 2010

机译：针对癌症治疗的选定药物遗传学测试的系统评价：CYp2D6用于乳腺癌中的他莫昔芬，KRas用于结肠直肠癌中的抗EGFR抗体，以及BCR-aBL1用于慢性髓性白血病中的酪氨酸激酶抑制剂。技术评估报告

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

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