PEG-grafted Hyperbranched Polyethyleneimine-Oxidized Single Walled Carbon Nanotube Complex (PEG-PEI-SWNT) for Sustained Delivery of Doxorubicin

摘要

To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeuticudagents (e.g. doxorubicin) in order to decrease doxorubicin toxicity and increase its efficacy, we aimed touddevelop a novel approach to aqueous disperse and stabilize SWNTs through consequent steps of oxidationud(oxSWNT) and PEG-PEI complexation (PEG-PEI-SWNT). Doxorubicin was loaded onto the modifiedudSWNTs in alkalione pH with more considerable capacity ( 900 %) than those previously reported, due toudcomplex formation with PEI proved by UV-visible spectroscopy. The loaded carrier was stable in physiologicudsimulated medium. Drug release was prolonged and dilution independent, but exhibited pH-dependentudburst release that makes SWNTs as suitable in vivo drug carriers in acidic tumor milieu.When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34928