Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions

摘要

Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b-udPEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamideud(MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmissionudelectron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregationudof PS-loaded micelles by their “coronas” that promoted the drug crystallization were established.udThe question about the presence of TBC micelles inside crystalline space was discussed.When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35235