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Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

机译:基于HPMC和藻酸钠的复合颊制剂可用于尼古丁替代疗法

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摘要

Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations were characterised using texture analyser (tensile and hardness, mucoadhesion), scanning electron microscopy, X-ray diffractometry, attenuated total reflection-Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC) and swelling capacity. Drug loaded films and wafers were characterised for content uniformity (HPLC) whilst the drug loaded wafers only were further characterised for in vitro drug dissolution. SA modified and improved the functional properties of HPMC at optimum ratio of HPMC: SA of 1.25: 0.75. Generally, both films and wafers (blank and drug loaded) were amorphous in nature which impacted on swelling and mucoadhesive performance. HPMC-SA composite wafers showed a porous internal morphology with higher mucoadhesion, swelling index and drug loading capacity compared to the HPMC-SA composite films which were non-porous. The study demonstrates the potential use of composite HPMC-SA wafers in the buccal delivery nicotine.
机译:由于在许多国家中严重的负面健康和经济影响,戒烟是当前的热门话题。这项研究旨在开发含HPMC和海藻酸钠(SA)的颊膜和威化饼,可通过颊粘膜作为尼古丁替代疗法的潜在用途,作为目前使用的尼古丁贴剂和口香糖的廉价但有效替代品。使用质地分析仪(拉伸强度和硬度,粘膜粘附力),扫描电子显微镜,X射线衍射,衰减全反射-傅立叶变换红外光谱(ATR-FTIR),差示扫描量热法(DSC)和溶胀能力对制剂进行表征。表征了载药薄膜和晶片的含量均匀性(HPLC),而仅表征了载药晶片的体外药物溶解。 SA以1.25:0.75的最佳HPMC:SA比例改进和改善了HPMC的功能特性。通常,薄膜和薄饼(空白和载药)本质上都是无定形的,这会影响溶胀和粘膜粘附性能。与无孔的HPMC-SA复合膜相比,HPMC-SA复合晶片显示出多孔的内部形态,具有更高的粘膜粘附力,溶胀指数和载药量。这项研究表明复合HPMC-SA晶片在颊输送尼古丁中的潜在用途。

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