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Using Sensitivity Analyses for Unobserved Confounding to Address Covariate Measurement Error in Propensity Score Methods

机译:使用敏感性分析进行不易察觉的混淆,以解决倾向得分方法中的协变量测量误差

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摘要

Propensity score methods are a popular tool to control for confounding in observational data, but their bias-reduction properties are threatened by covariate measurement error. There are few easy-to-implement methods to correct for such bias. We describe and demonstrate how existing sensitivity analyses for unobserved confounding---propensity score calibration, Vanderweele and Arahu27s bias formulas, and Rosenbaumu27s sensitivity analysis---can be adapted to address this problem. In a simulation study, we examined the extent to which these sensitivity analyses can correct for several measurement error structures: classical, systematic differential, and heteroscedastic covariate measurement error. We then apply these approaches to address covariate measurement error in estimating the association between depression and weight gain in a cohort of adults in Baltimore City. We recommend the use of Vanderweele and Arahu27s bias formulas and propensity score calibration (assuming it is adapted appropriately for the measurement error structure), as both approaches perform well for a variety of propensity score estimators and measurement error structures.
机译:倾向得分方法是控制观测数据混淆的一种流行工具,但是其偏倚降低特性受到协变量测量误差的威胁。很少有易于实现的方法来纠正这种偏差。我们描述并演示了如何将针对未观察到的混淆的现有灵敏度分析(倾向得分校准,范德韦尔和Arah的偏差公式以及Rosenbaum的灵敏度分析)进行调整以解决此问题。在模拟研究中,我们检查了这些灵敏度分析可在多大程度上校正几种测量误差结构:经典误差,系统微分误差和异方差协变量测量误差。然后,我们使用这些方法来解决协变量测量误差,以估计巴尔的摩市成年人群中抑郁与体重增加之间的关联。我们建议使用Vanderweele和Arah u27的偏差公式和倾向得分校准(假设它已针对测量误差结构进行了适当调整),因为这两种方法对于各种倾向得分估计器和测量误差结构均表现良好。

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