A research on development of automatic 2D/2D image registration system for digitally reconstructed radiographs (DRR) and electronic portal imaging devices image (EPID) has been carried out to verify patient position in radiotherapy treatment. Registration is done using two methods: rigid transformation and mutual information. Implementations using rigid transformations yields X-axis average translation (2,18??0,89) mm, Y-axis (1,18??0,59) mm as well as Z-axis (2,08??0,9) mm while the average registration time which is (42.85??15.20) s. Implementations using mutual information yields X-axis average translation (2,27??0,8) mm,Y axis (1,89??0,65) mm as well as Z axis (0,94??0,59) mm while the average registration time which is (2.85??0.54) s. We can conclude that there is no significant difference in P value > 0.05 according to chi square test corresponds to verification manual, semiautomatic fusion, rigid transformations, and mutual information.
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