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FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.

机译：与急性髓样白血病患者的FLT3内部串联重复相比，FLT3酪氨酸激酶结构域突变在生物学上有所区别，并且预后要好得多。

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Mead AJ; Linch DC; Hills RK; Wheatley K; Burnett AK; Gale RE;
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1. 急性髓系白血病患者外周血细胞中FLT3基因表达与FLT3/ITD突变的关系及其意义 [J] . 徐兵, 史鹏程, 宋小燕, 癌症（英文版） . 2009,第006期
2. Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication. [J] . Mead AJ, Gale RE, Kottaridis PD, British Journal of Haematology . 2008,第4期

机译：具有FLT3酪氨酸激酶结构域突变的急性髓样白血病母细胞对lestaurtinib的敏感性低于具有FLT3内部串联重复的那些。
3. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis [J] . M Yanada, K Matsuo, T Suzuki, Leukemia . 2005,第8期

机译：FLT3内部串联复制和酪氨酸激酶结构域突变对急性髓样白血病的预后意义：荟萃分析
4. Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia. [J] . Steudel C, Wermke M, Schaich M, Genes, Chromosomes and Cancer . 2003,第3期

机译：956名成年急性髓性白血病患者的MLL部分串联重复和FLT3内部串联重复突变的比较分析。
5. Internal Tandem Duplication of FLT3 and Activating Mutation of D835 Analyses in AML and MDS Patients [C] . C. Lo Nigro, D. Mattei, N. Mordini, European Haematology Association . 2002

机译：FLT3的内部串联复制和AML和MDS患者D835分析的激活突变
6. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
7. High fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: a prospective pilot study from India [O] . Surender Kumar Sharawat, Vinod Raina, Lalit Kumar, 2016

机译：高fms样酪氨酸激酶3（FLT3）受体表面表达预测成人急性髓样白血病的FLT3内部串联重复（ITD）阴性患者的不良结局：来自印度的一项前瞻性先导研究
8. Activating internal tandem duplication mutations of the fms-like tyrosine kinase-3 (FLT3-ITD) at complete response and relapse in patients with acute myeloid leukemia [O] . A. Nazha, J. Cortes, S. Faderl, 2012

机译：在急性髓性白血病患者的完全反应和复发时激活FMS样酪氨酸激酶-3（FLT3-ITD）的内部串联重复突变

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.

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