An efficient intermolecular Pd-catalyzed C–C and intramolecular Cu-catalyzed C–O bonds formation: synthesis of functionalized flavans and benzoxepine

摘要

An efficient three-step strategy for the synthesis of functionalized flavans, starting from readily available 2-bromoiodobenzenes and aryl vinyl alcohols, is presented and successfully extended to benzoxepine. An intermolecular [Pd]-catalyzed C–C and an intramolecular [Cu]-catalyzed C–O bond formations have been employed as key transformations of the strategy.