Antimicrobial activity of methanol extract of Citrullus colocynthis against antibiotic-resistant Staphylococcus aureus

摘要

Background and aims: Staphylococcus aureus and anaerobic gram-positive cocci, areudmedically the most important species in the genus Staphylococcus. Sometimes, the bacteriaudare called S. aureus. The constantly growing antibiotic-resistant bacterium is veryudimportant in treatments. The aim of this study was to evaluate the antimicrobial activity ofudethanol extract from Citrullus colocynthis against the S. aureus resistant to antibiotics.udMethods: S. aureus strains were isolated from the city of Zabol and C.colocynthis extractudwas prepared using rotary Department of Biology, Payame noor University, Tehran, Iranuddevices and the MIC and MBC were determined by microdilution method.udResults: The results of this study showed that the extract from C. colocynthis inhibits theudgrowth of bacteria in different concentrations, and that despite the relative strength ofudmost species with different concentrations, the highest sensitivity was observed inudconcentrations of 10 and 20 mg/ml, in which is 100% bacteria were gone. C. colocynthisudextract at a concentration of approximately 5 mg /ml had the highest inhibitory effect.udConclusion: The results showed high antimicrobial effects of ethanol extract ofudC. colocynthis, which can offer appropriate drug therapy.