CLOSE RELATIONSHIP OF CAROTID INTIMA-MEDIA THICKNESS WITH LEFT VENTRICULAR HYPERTROPHY AND EJECTION FRACTION IN END-STAGE RENAL DISEASE PATIENTS UNDERGOING HEMODIALYSIS TREATMENT

摘要

Background- Two principal findings of cardiovascular disease in end-stage renal diseaseudpatients undergoing regular hemodialysis are left ventricular hypertrophy (LVH) andudarterial disease due to rapidly progressive atherosclerotic vascular disease that can beudcharacterized by an enlargement and hypertrophy of arteries (intima-media complexudthickening, IMT). In this study, we sought to study the relationship between leftudventricular hypertrophy with intima-media complex thickening in end-stage renaluddisease patients undergoing regular hemodialysis.udMethods- Sixty-one unselected patients with end-stage renal disease (ESRD) who wereudundergoing regular and maintenance hemodialysis treatment (F=23, M=38) wereudstudied. The subjects consisted of 50 non-diabetic hemodialysis patients (F=20, M=30)udand 11 diabetic hemodialysis patients (F=3, M=8). For all the subjects,udechocardiography and carotid intima-media thickness measuring by B-modeudultrasonography were performed.udResults- In this study, there was a positive correlation between stages of LVH with durationudof hemodialysis treatment, stages of hypertension (HTN), and with carotid-IMT. Audpositive correlation was also seen between stages of LVH and presence of chest pain,udand more thickening of the intima-media complex was seen in the diabetic group.udDiabetes mellitus was associated with the presence of chest pain, as was positiveudcorrelation between stages of HTN with IMT, and a reverse correlation was observedudbetween IMT with the percent of cardiac ejection fraction.udConclusion- Prevalence of thickening in intima-media complex is more evident inudhemodialysis subjects with LVH. When there is LVH, IMT is similar in severity to theudLVH (Iranian Heart Journal 2006; 7 (1): 40-46).