Therapeutic effects of Quercus persica l fruit skin on healing of second-degree burn wounds in animal model

摘要

Background and Objective: Second-degree burns are associated with several complications such as infection, septicemia, and unpleasant skin appearance and are one of the main causes of in-hospital mortality. Therefore, this study was designed to determine the therapeutic effects of Q. persica fruit skin on the healing of second-degree burn wounds.udMaterials and Methods: In this experimental study, 60 mice were randomly assigned into three groups. Vaseline was used for group 1, 1% Silver sulfadiazine (SSD) cream was used for group 2, and Vaseline-based Quercus persica L. hydroalcoholic extract was used for group 3. After the development of second-degree burns with a pathologist’s confirmation, the wound area was measured for a month by AutoCAD software. The wound was pathologically examined and data were analyzed by repeated measures ANOVA and Kruskal-Wallis using SPSS 18.udResults: Decrease in wound area was 72.01% in the Quercus persica L. group, 65.95% in the SSD group, and 59.12% in the Vaseline group. Mean wound recovery was higher in the Q. persica fruit skin group but not significant (P>0.05). The mean number of wound hair follicles and sebaceous glands and mean wound angiogenesis were higher while wound inflammation intensity was lower in Quercus persica L group, but no significant difference in these variables was seen between the Quercus persica L and SSD groups (P>0.05).udConclusion: Quercus persica L. had relatively acceptable therapeutic effects on the healing of second-degree burn wounds compared to SSD and Vaseline.