Methyltrichlorosilane-DMSO: A Facile and Highly Efficient Recipe for the Chlorination of Enamides and Enecarbamates

摘要

A facile and highly efficient method was developed for the chlorination of enamides and enecarbamates with the combined use of methyltrichlorosilane and DMSO, which allowed one-pot production of the corresponding P-chloro enamides and enecarbamates in high yield and good stereoselectivity. This method is easy to operate and suitable for both cyclic and acyclic substrates.