Chromones and coumarins from the dried fructus of Cnidium monnieri

摘要

Chemical investigations on the ethanolic extract of the dried fructus of Cnidium monnieri offered three chromones and eight coumarins. Among them, a new chromone and a new coumarin were identified and elucidated as 5,7-dihydroxy-6-[(2Z)-4-(beta-D-glucopyranosyl) oxy-3- methylbut-2-enyl]-2-hydroxymethyl-4H-1-benzopyran-4-one (1, hydroxycnidimoside A) and (ref 1'S,2'R)-8-(2,3-epoxy-1-hydroxy-3-methylbutyl)-7-methoxycoumarin (8, hydroxyosthole epoxide), respectively, by extensive analyses of spectroscopic data including 1- and 2-D NMR, MS, UV. OR, IR. and HRMS data. The other known compounds were identified by analyses of spectroscopic data and by comparison with literature reported. (C) 2011 Elsevier B.V. All rights reserved.