Selective Determination of Uric Acid in Presence of Ascorbic Acid and Dopamine at Neutral pH Using Exfoliated Graphite Electrodes

摘要

Exfoliated graphite electrodes have been used to detect uric acid at neutral pHs, by following its oxidation. A linear range of 5-53 mu M and a detection limit of 5 mu M are observed at a pH of 7.0. Uric acid was found to be selectively adsorbed on exfoliated graphite surface in the presence of excess ascorbic acid. This leads to its selective determination in the presence of ascorbic acid. Simultaneous detection of uric acid, dopamine and ascorbic acid has also been demonstrated on exfoliated graphite electrodes in a pH 7 buffer.