The Potential Role of Nicotine in the Treatmentudof Learning and Memory Impairment after REMudSleep Deprivation

摘要

Sleep deprivation has become a contributing factor to the world’sudhealth concerns such as cardiovascular disease, mental illness and inattentivenessudin occupationand decision making. It can also disturb synaptic plasticity thatudcan lead to learning and memory impairment. Therefore, boosting cholinergicudactivity using acetylcholine imitator that can be found in the tobacco plant,udknown as nicotine, is essential in reversing the negative influences of sleep lossudin the brain. Thus, studies on the effects of nicotine treatment on molecularudmechanisms and structural changes of hippocampal brain cells are vital in orderudto gain more understanding and to overcome the detrimental consequencesofudlearning and memory impairment related to sleep divest.