Exercise-induced fatigue in severe hypoxia is attenuated in healthy humans following an intermittent hypoxic protocol

摘要

Severe, acute hypoxia leads to an increased development of supraspinal fatigue during whole body exercise (1). This is alleviated following acclimatisation to severe altitude (2), although the development of peripheral fatigue is not (3). Prolonged exposure to severe altitude involves substantial logistical demand, a high incidence of acute mountain sickness and immunological consequences. We assessed the mechanisms of exercise-induced fatigue in severe hypoxia before and after a protocol of intermittent hypoxic exposure and training.