Mitogenic signaling by Gq/11-coupled receptors

摘要

By binding to their cognate GPCRs, many potent mitogens such as neuropeptides, angiotensin II or lysophosphatidic acid stimulate cell proliferation via engaging the ERK/MAPK cascade. As mentioned before, agonists stimulating Gq/11-coupled receptors activate PLCb isoforms thereby activating PKCs and elevating [Ca2+]i. These two second messengers represent key molecules for coupling Gq/11 proteins to the ERK/MAPK cascade. In this work, by means of GnRH in gonadotropic aT3-1 cells and galanin or bradykinin in SCLC cells, different aspects of Gq/11-dependent mitogenic signaling pathways were revealed. Our findings together with previous reports underline the notion that signaling pathways emanating from Gq/11-coupled receptors are tightly regulated in a cell- and receptor-specific manner.