Research of several medicine matrixes had been done. Matrixes used in the udresearch are montmorillonite, Na/montmorillonite, chitosan (medium molecular weight), udchitosan (low molecular weight), composite of montmorillonite-chitosan chitosan ud(medium molecular weight), and composite of montmorillonite-chitosan chitosan (low udmolecular weight). Those matrixes are tested for sustain release of theophylline. HPMC udwas used for positive control. And conventional tablet of theophylline was used for udnegative control. udCharacteristics investigated are physical properties of granule (flow time, tapping udindex, and compressibility) and physical properties of tablet (uniformity of weight, udhardness, brittleness, and degradation time). Tablet qualified was test by dissolution test. udThe physical properties of granule (flow time) is qualify i.e. under 10 s. Tapping udindex was qualify i.e. under 20 %. Tablets had good compressibility. The brittleness of udtablet was not qualified i.e. above the standard limit. The property of dissolution was udslower than negative control. And the properties of dissolution at the 180udthudminute were udslower than positive control.
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